"Sarakunan huxu" na COVID - Tuni 19 Motant iri

Pandemic na sabon abu na sabon gige gipasar da ya haifar da asara da tasirin tattalin arzikin duniya, musayar al'adu da rayuwar mutane a duniya. Har zuwa yanzu, kodayake haɓakar cutar ta duniya ta kasance da kyau kuma ana sarrafawa. Koyaya, tare da maye gurbi naCOVID - 19, wasu ƙasashe sun fara fitowa da ƙwayoyin cutar da ke ba da sauri. Daga gare su, sabon bambance bambancen Coronavirus da suka faru a Burtaniya, Afirka ta Kudu, Brazil, India, da sauransu, da dai sauransu.

• Thapha ya bayyana a Ingila a watan Satumbar 2020 kuma ya haifar da karuwa a cikin yanayin hunturu, kawo United Kingusin baya cikin kulle a watan Janairu. Wasu ƙasashe suna kusa, musamman ma a Turai. A cewar Hukumar Lafiya ta Duniya, ta zama irin zurfin zuriya a Amurka a farkon Afrilu, kuma na Mayu 25, aƙalla ƙasashe 149 sun ruwaito wannan zuriya.
• Beta ya bayyana a Afirka ta Kudu a watan Agusta 20 ga Agusta, jagorar dawowar COVID - 19 Halin, ya sa Kudancin Afirka. Bayan 25 ga Mayu, aƙalla ƙasashe 102 sun ba da rahoton wannan lamarin.
• An fara gano Gasar Gamma a cikin garin Amaus a watan Disanaus 2020, yana haifar da tsarin kiwon lafiya na Brazil da kuma haifar da karancin kiwon lafiya. Kamar 25 ga Mayu, akalla kasashe 59 sun ba da rahoton wannan lamarin.
• An fara gano Delta a Indiya a watan Oktoba 2020, kuma na makara Mayu, an samo kwayar cutar a akalla kasashe 54. Kungiyar Masu ba da shawarar Kimiyya ta Burtaniya ta Burtaniya ta bayyana a ranar 13 ga Mayu na iya isar da watsawa sama da 50% sama da na Alfa Bambanci

A shekarar 2019 - NCOv na beta na beta na coronaviruses. Yana da guda ɗaya - keɓaɓɓen tabbatacce - Cire cutar RNA tare da ambulaf. Abubuwan da barbashi suna zagaye ko elliptical kuma suna da diamita na 60 - 140nm. Yana da kwayoyin halittar 5, wanda ke da bi rubuta 4 tsarin gini naFurotin nucleocasid (N),Envelon furotin (E),Membrane furotin (m) daStuƙiGlycoprotein (S), daHEmagglutinin - Estoredimer (RDRP). DaFurotin nucleocasid (N) kunsa da RNAE na kwarai don samar da tsayayyen nucleocapsid. Nucleocapsid yana kewaye da ambulaf mai cutar (e) don kariya. A cikin ambulaf din kwayar, akwaiMembrane furotin (m) daStuƙiGlycoprotein (S) madaidaicin furotin. Daga gare su, sabon coronavirus yana amfani da furotin fushin ƙasa don ɗaure sel, sannan ku mamaye sel. Spike glycopotin ma muhimmiyar tsari ga tsarin rigakafi don amincewa da ƙwayoyin cuta kuma suna hana su tare da rigakafin. Wadannan sabbin cututtukan cututtukan moronavirus suna daidai saboda maye gurbi a cikin wasu mahimman shafuka glycoproter (s), wanda ke haifar da mahimman abubuwa ko tare da dakatar da rigakafin rigakafin. Wannan ya ci gaba da cewa wadannan nau'ikan mutane huɗu sun zama babban matattararsu a halin yanzu.

Babban halaye na Alfa da Alfa Mutant S sunadaran sune kamar haka:

Teamungiyar ta jagoranta da Farfesa Chen Bing daga makarantar Harvard Likitocin da kuma asibitin Boston kwanan nan sun buga jerin sakamakon bincike a cikin Jaridar Shaida. Amino acid ya canza A570D da S9822A suna taimaka wa dillali furotin furotin don kiyaye yankin da ke karbar yanki a matsayin da ya shafi mai karba. A lokaci guda, N501y yana ƙara yawan ƙarfin ɗaure na ƙarfin ƙarfafa yankin zuwa Domain mai karɓa zuwa Domain na Ace2 Reccepor. Masu binciken suna tantance cewa waɗannan canje-canjen na iya ba da bambance-bambancen Alfa don cutar da nau'in sel waɗanda suke da karɓar Ace2.

Sakamakon binciken ya kuma nuna cewa a cikin ƙwayar Beta, furotin na da ci gaba da riƙe tsarin datsa na G614 kuma yana da kusan irin ra'ayi iri ɗaya. N501Y, K417n da E484k a RBD bai haifar da babban canje-canje na tsari ba, amma asarar kayan adon gishiri tsakanin dangogi na zamani da N501Y. K417N da E484K na iya haifar da rigakafin manufa RBD - 2 evitope don rasa daurin da aka rasa da tsinkaye. Mayar da maye gurbi a cikin NTD Refeshpe saman Antigen kuma a rage tasiri mafi inganci na neutrizing a kan Ntd - 1 paritope. Wataƙila ana zaɓar bambance-bambancen beta a ƙarƙashin takamaiman matakin rigakafi

Babban fasali na Gamma Mutant s furotin:

A cikin binciken da aka buga a cikin ilimin mu na Jarida a ranar 14 ga Afrilu, 2021, kungiyar masu bincike game da Gasaravirus wanda ya bayyana a Brazil. Sakamakon ya nuna cewa cutar gamma ta ce sau 17, 10 wanda ke nan a cikin bambance-bambancen mazuwa, N501Y, E484T, da K417t. N501Y da K417t suna hulɗa da aniotensin ɗan adam - Canza enzyme 2 (Ace2), yayin da E484K is located a cikin madauki Ace2 dubawa. Yana da mahimmanci a lura cewa waɗannan bambance-bambancen guda uku na Afirka ta Kudu (beta, B.1.351) wanda ya sami hankali sosai, kuma N501y yana nan a cikin bambancin Biritaniya (alpha, b.1.1.7). Saboda sun yi kama da bambancin ƙwayar cuta da ƙarfi ga sel na mutane, a wasu yanayi, don taimakawa abubuwan rigakafi.

Babban fasali na Delta Mutant S furotin:

Wani labarin da aka buga a kan dandamali na BIORXIV a ranar 17 ga Yuni, 2022) An kiyaye maye gurbi na P681R a cikin binciken Delta (B.1.617). Ta hanyar - zurfin bincike, an gano cewa maye gurbi na P681r inganta Furin - Sunada izinin share furotin da kara su - Furucin tantanin halitta. Kuma don inganta maye gurbin P681 don inganta karfin kwayar cutar ta tsira daga kawunan rigakafin abubuwa.

Dangane da halayen abubuwan da suka faru da kuma halayen 'sarakunan huxu "naCOVID - 19 Iri na Mutant, ana iya ganin cewa cutar ta cikin gari za ta zama yanayin al'ada ta cutar ta duniya. A hankali ya amsa manufar rigakafin cutar ta bishara ta bishara - Spectrum da ingantaccen maganin cututtukan kambi zai zama mai ƙarfi makamanmu a kan annoba.

(Tushen data: Wanene)