"Madzimambo mana" eCoDD - 19 Mutant Drain

Pasi rose denderedzwa reiyo yeCrown Denda rakakonzera kurasikirwa kukuru uye kukanganisa pakukura kwepasirese, kuchinjanisa kwetsika uye nehupenyu hwezuva nezuva hwevanhu pasi rese. Kusvika zvino, kunyange kukura kwedenda repasi rose kwakadziviswa zvakanyatso kudzivirirwa uye kudzorwa. Nekudaro, nekumukira kweCHADD - 19, dzimwe nyika dzakabuda dzakatenderedza dzinotenderera dzakapararira nekukurumidza. Pakati pavo, New Coronavirus akasiyana ayo akaitika muUnited Kingdom, South Africa, Brazil, India, etc. inogona kutsanangurwa se "madzimambo mana" ematambudziko ematambudziko.

• ALPHA yakaonekwa muEngland munaGunyana 2020 uye yakakonzera kuvhiyiwa munguva yechando, kuunza United Kingdom back muvhiyi munaJanuary. Dzimwe nyika dziri padyo, kunyanya muEurope. Maererano neWorld Health Organisation, yakava danho rakakura muUnited States mukutanga kwaApril, uye saMay 25, nyika dzinoverengeka dzakataura izvi.
• Beta yakaonekwa muSouth Africa muna Nyamavhuvhu 2020, inotungamira kudzoka kweiyo Chandende - 19 Mhosva, ichitsvaira Southern Africa. Kubva paMay 25, angangoita zana nemakumi mashanu nyika vakataura izvi mamiriro.
• Gamma yakatanga kuwanikwa muAmazon Guta reManaus muna Zvita 2020, zvichikonzera kuwanda kwematare, kuchinjisa hutano hweBrazil uye kukonzera kushomeka kweokisijeni. Kubva muna Chivabvu 25, angangoita mazana mashanu nyika akataura izvi mamiriro.
• Delta akatanga kuwanikwa muIndia muna Gumiguru 2020, uye sekupera kwaMay, hutachiona hwakawanikwa munyika dzinosvika makumi mashanu neshanu. Iyo yeBritish emergency Science Science Group yakataurwa muna Chivabvu 13 iyo yekufambisa kwayo inogona kunge iri 50% yakakwirira kupfuura iyo yeiyo yeiyo alpha mutsauko

Iyo 2019 - NCOV ndeyako yeBeta genus yeCoronaviruses. Icho chimwe chete - chakasarudzika zvakanaka - vakabatiswa hutachiona nehamvuropu. Izvo zvimedu zvinotenderera kana elliptical uye uve neyineti ye60 - 140nm. Iyo ine marudzi mashanu akakosha, ayo anoenderana neyakaganhurira 4 mrotelurpurity eNuleocapsid protein (N),Envelop protein (E),Membrane protein (m) uyeSpikeGlycoprotein (S), uyeHEmagglutinin - Esterasedimer (RDRP). The theNuleocapsid protein . Iyo nucleocapsid yakakomberedzwa nehamvukuru viriviki (e) kuti udzivirirwe. Munhandare yehutachiona, paneMembrane protein (m) uyeSpikeGlycoprotein (S) yakaenzana protein. Pakati pavo, iyo itsva coronavirus inoshandisa iyo Spike Spike protein yekusungira kune vanogamuchira cell, uye ipapo maColled masero. Spike glycopotein zvakare chakakoshesa mamiriro eiyo immune system yekuona mavairasi uye nekuvandudza ivo nemishonga yekurapa. Izvi zvina zvitsva zveCornavirus matinji zvinyatsoita nekuda kwekushandurwa mune dzimwe nzvimbo dzinokosha dze spike yeiyo mutambi madhiri nefoni kana neyakaora antibodies. Izvi zvakatungamira kune aya mana mutant commancins achiva matinini makuru parizvino.

Hunhu hukuru hweAlfa naBeta Mutant S map mapuroteni ari seinotevera:

Chikwata chakatungamirirwa naProfess Amino Acid inoshandura A570D uye S982A batsira iyo Spike Protein Trimer yekuchengeta yeRetptor Inosunga domain munzvimbo painenge ichibatanidza kune iyo Receptor. Panguva imwecheteyo, N501Y inowedzera kusunganidzwa kwekubatana kweiyo Receptor kusunga domain kuenda kuAce2 Receptor. Vanotsvaga vanorangarira kuti shanduko idzi dzinogona kubvumira alpha dzakasiyana-siyana kune vasina kutapurira marudzi marudzi ane mashoma eAce2 Receptors.

Mhedzisiro yeChikwata yeChikwata inoratidzawo kuti muhutachiona hwehutachiona, iyo protein yakakura inochengetedza chimiro cheG614 trimer uye ine zvingangoita zvakafanana biochemical kugadzikana. N501Y, K47n naE484k muRbd hazvina kukonzera shanduko huru, asi kurasikirwa kwemapango emunyu pakati pe k417 K417N uye E484K inogona kukonzeresa antibodes inotarisira RBD - 2 Epitope yekurasikirwa nekusunga uye kusarerekera. Izvo zvinoperekedza met Beta Variya vanogona kunge vachisarudzwa pasi peimwe degree rekushanduka kwemuviri

Iyo huru maficha eGAMMA MUTANT S Pronein:

Mune chidzidzo chakabudiswa munhoroondo yesainzi musi waApril 14, 2021, timu yepasirese yevaongorori yaiitisa kutsvagisa zvine chekuita nekuongororwa kwegamma (P.1) New Coronavirus akasiyana muBrazil. Mhedzisiro yacho inoratidza kuti Gamma (P.1) hutachiona hwakasarudzika AMino Acid shanduko, 10 zvevakararama zvirimo N501Y uye K417T International neAngiotensin - Kushandura Enzyme 2 (Ace2), nepo E484k iri munzvimbo ine loop kunze kweiyo Ace2 interface. Zvakakosha kucherechedza kuti aya matatu akasiyana aripo aripo muSouth Africa Varsion (Beta, B.1.351) izvo zvakagamuchira kutarisisa, uye N5Y iripo muBritish musiyano (Alpha, B.1.1.7). Nekuti vanoita kunge vanoita kuti hutachiona husina hutachiona hwakasimba zvakanyanya kumasero evanhu, mune dzimwe nguva, kubatsira kuendesa antibodies.

Izvo zvinhu zvikuru zveDelta Mutant S Pronein:

Chinyorwa chakaburitswa pane iyo Biorg chikuva musi waJune 17, 2021 yakatemwa kuti iyo P681T Muter yakachengetedzwa zvakanyanya muDelta (B.1.617) mutsara weDelta (B.1.617) Variya. Kuburikidza ne - Yakadzika kutsvagisa, yakawanikwa kuti mutaundi weP681R akamisikidza furin - yakadururwa cleavage yeiyo spike yeiyo protein uye yakasimudzirwa cell. Uye kusimudzira iyo P681 kushandisikidza kusimudzira kugona kwemutsiriyo kupukunyuka kurira kurira kuronga.

Zvinoenderana nedenderedzwa uye maEtiological hunhu hwe "madzimambo mana" aCHADD - 19 Mutant Strain, zvinogona kuoneka kuti denda remunharaunda yedenda racho richave rakajairika mamiriro edenderedzwa repasi rose. Kunyamarira kupindura kune chirwere chepasi rose yedenderedzwa rekudzivirira uye kutsvaga yakafara

(Data sosi: ndiani)