Intshayelelo
I-Dengue Fever, i-mosquito - Isifo esine-vilne se-villa, siyifaka umngeni wezempilo, ngakumbi kwimimandla enamatye kunye ne-pubropical. Esi sifo sibangelwa ziindlela ezine ezahlukileyo kwi-Dengue Virus (iDenv1 - 4), nganye ikwazi ukuqhuba ukubonakaliswa okukhulu kweklinikhi, kubandakanya i-demorrhagic fever (DHF) kunye ne-Dengue Shock Syndrome (DHF) Njengoko abasemagunyeni bezempilo esidlangalaleni bazabalazela ukunciphisa ifuthe le-Dengue, ukuqonda indima yenkqubo yokuzikhusela, ngakumbi i-IGM Antibodies, ukuphendula intsholongwane kwaye isifo sibalulekile.
● I-pidemiology ye-Dengue
I-Dengue Fever ichaphazela izigidi qho ngonyaka, nge-curge engagungqiyo kumatyala kule minyaka imbalwa idlulileyo. Olu nyuso lungachazwa ngokufudukela kwabantu ezidolophini, ukonyusa ukuhamba kwabantu, kunye notshintsho lwemozulu. Umbutho wezeMpilo weHlabathi uqikelela ukuba isidima esisulela abantu abazizigidi ezingama-390 minyaka le, nge-96 yezigidi ezibonisa iimpawu zekliniki. Esi sifo sibeka umthwalo obonakalayo wentlalontle, ichaphazela iinkqubo zempilo, uqoqosho, kunye noluntu kwihlabathi liphela.
● Inkxalabo yezempilo yehlabathi
Ukuxhaphaka kukaDengoe kumazwe angaphezu kwe-100 kuye kwenza ukuba ibe yinkxalabo yezempilo yehlabathi. Imimandla efana ne-mpuma yeAsia, iLatin America, kwaye iziqithi zePasifiki zichaphazeleka ngokungakhathali. Ngaphandle kwimpembelelo ethe ngqo kubantu, uDengue offhees Sheakes Izixhobo zempilo kwaye unokukhokelela kwilahleko yezoqoqosho. Ngenxa yoko, ukuphuhlisa izixhobo zokuqonda zokuxilonga kunye namanyathelo okhuseleko kubaluleke kakhulu ukulawula ukusasazeka kwesifo.
Impendulo yomzimba kwi-dengee
● Iindlela zokhuselo lomzimba
Amajoni omzimba omzimba ngumgca wokuqala wokuzikhusela kwi-Denguue Shois Lafes. Emva kosulelo, iimpendulo ze-interte amajoni asebenze ukunciphisa ukuphindaphinda intsholongwane. Nangona kunjalo, i-goaverive yamajoni omzimba, ebandakanya i-lymphocytes kunye ne-antis yomntu, idlala indima ebaluleke ngakumbi ekulawuleni isifo.
● Ukubaluleka Kubachasi
Ii-antibodies zibaluleke kakhulu ekuchongeni nasekuthatheni iintsholongwane njengentsholongwane intsholongwane. Ii-antibodies ezimbini eziphambili,UgonoI-Globulin M (I-Igm) kunye ne-igm) g Basebenza njengezalathi zenqanaba losulelo kunye noncedo ophakathi kosulelo oluphambili nolwesibini.
I-Igm Antibodies kunye nosulelo olucekeceke
● Ixesha elifanelekileyo lemveliso ye-Igm
Ii-Antibodies ze-IGM zezokuqala ukuvela emva koko usulelo lwentsholongwane. Ngokwesiqhelo ifunyanwe ngaphakathi kwe-3 - Iintsuku ezi-5 emva kokuqala kweempawu, ubukho babo bubonisa usulelo lwamva nje. Amanqanaba e-IGM encothula iiveki ezimbini, usuleleke kwaye ngokuthe ngcembe wehla, nyamalala emva kwe-2 - iinyanga ezi-3.
● Ukubaluleka kwe-IGM ekufumaneni isifo
Ubukho be-IGM kubalulekile kwisifo sokuqala somkhuhlane wabantu. Ibonisa usulelo olusebenzayo kwaye linokukhokela oogqirha bezempilo kunyango ngexesha elifanelekileyo kunye nokulawulwa kwesi sifo. Ngenxa yoko, izixhobo zokuvavanya i-IGM ziye zaba sisitampu kwimimandla eqhubeka nokuqhambuka.
I-IGG Antibodies: Izalathiso zeXesha elidlulileyo nelangoku
● Ukwahlula i-Igg kwi-IGM
I-Igg Antibodies ivela kamva ngexesha losulelo lokusweleka, ngokufuthi likufundela kwiveki yesibini yosulelo. Ngokungafaniyo I-IGM, i-Igg iqhubeka kwigazi, ebonelela ixesha elide - igama eliqinisekileyo. Ubukho be-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-I-IGG ichaza ukuvezwa kwentsholongwane kwaye inokukhupha usulelo lwesibini.
● Indima ye-IGG ekuchongeni usulelo
UkuQeqwa kwe-IGG kuye kwenza ukuba kubaluleke kakhulu ekuvavanyeni ukuvezwa kwangaphambili kunye namanqanaba okugonya. Kwisifo sosulelo lwesibini, impendulo ye-Igg kwaye impendulo eyomeleleyo inokunyusa ubungakanani besi sifo, ukwenza ukuba kufunyenwe kuvavanyo lweklinikhi.
Ukuvavanywa kunye nokufumanisa ukosuleleka kosulelo
● Ixesha kunye nokuphumelela kovavanyo lwee-anting
Isifo esichanekileyo sibalulekile kubaphathi abafanelekileyo. Iimvavanyo ze-Antign, ezifumana iiproteni zentsholongwane, ziyasebenza kwinqanaba lokuqala losulelo (kwiintsuku ezi-5 zokuqala). Nangona kunjalo, emva kweli xesha, iimvavanyo ezintiyo (i-Igm kunye i-IGG) zinokuthenjwa ngakumbi. Ukufumaneka kweloI-Dengue Fever Igg kunye I-IgmIikhithi zovavanyo ezivela kubavelisi kunye nabathengisi baququzelela ukuvavanywa ngokubanzi kwimimandla yesiphelo.
● Ukutolikwa kweziphumo zovavanyo
Iziphumo zokuQalisa zibalulekile ukwahlula phakathi kosulelo oluphambili nolwesibini. I-IGM elungileyo ene-Igg engalunganga okanye ephantsi iphakamisa usulelo oluphambili. Kwelinye icala, i-igg ephezulu kunye namanqanaba ahlukeneyo e-Igm inokubonisa usulelo lwesibini, olufuna ukubeka esweni ngokusondeleyo ngenxa yeengxaki ezinokubakho.
Imiceli mngeni ekuchongeni umkhuhlane
● Iimpawu ezigqithisileyo
UDengue wabelana ngeempawu zeklinikhi kunye nolunye usulelo lwentsholongwane enje ngeZika, Chikutunya, kunye neCovided -. Iimpawu ezinje ngomkhuhlane, iintlungu ezidibeneyo, kwaye iirabha zingakhokelela kwi-sussiginagenosis. Ke, uvavanyo lwelebhu luba lubalulekile ngokwahlula phakathi kwezi zifo.
● Ukubaluleka kovavanyo lwelebhu
Iimvavanyo zelebhu, kubandakanya iRT - PCR kunye ne-ELISA, ukubonelela ngocingo oluchanekileyo lwe-dengue. Ukuphuhliswa nokuhanjiswa kweekhithi zovavanyo ezinokuthenjwa yi-Dengue Fever Igg kunye nabavelisi be-Igm kunye neefektri ziqinisekisa ukuba amaziko ezempilo axhotyisiwe ukuqhuba i-Expressionscares.
Izikhokelo ze-CDC zovavanyo lweDieee
● Iingcebiso
Amaziko olawulo lwezifo kunye nokuthintela (i-CDC) acebisa ngokuxhomekeka kwi-IGG ye-Igg ye-Gengue ye-Dengue ye-Dengue ngenxa ye-Cross - Ukusebenza kwakhona. Endaweni yoko, ukudibanisa uvavanyo lweklinikhi kunye ne-IGM kunye neemvavanyo ze-Igg ivelisa eyona nto ixinezelekileyo yokuxilongwa okuthembekileyo.
● Iindlela ezilungileyo zokuchonga
Ukuxilongwa ngempumelelo kwesifo, oogqirha bezempilo kufuneka bathathele ingqalelo ukwanda kwesifo, uphawu lwe-fatset, kunye nembali yomonde. Ukusetyenziswa kwe-dengue dengue Fever Igg kunye neeKom zokuvavanya i-Igm kubathengisi abahlonelayo kuqinisekisa ukubambelela kwizikhokelo ze-CDC kunye nokuphucula ukuchaneka kovavanyo.
Ukuthelekisa iimpawu zesidima kunye nolunye usulelo
● Iimpawu eziqhelekileyo
Iimpawu zikaDengue zihlala zigquma nolunye usulelo, zibonisa inkqubo yokuqonda. I-fever, intloko ebuhlungu, imisipha kunye nentlungu edibeneyo, kwaye i-rashes ixhaphakile kuzo zonke izifo ezininzi zentsholongwane, inyanzelisa isiqinisekiso selebhu.
● Ukuxilongwa okwahlukileyo
Ababoneleli bezempilo kufuneka balondoloze nesalathiso esiphezulu sokukrokrela ukuba uDengue kwimimandla ye-Edeemic, ngakumbi ngexesha lokuqhambuka. Umnqamlezo - Ukubuyiselwa kweziphumo zeklinikhi ngeziphumo zelebhu kunceda ukwahlula ungubani na ovela kwezinye izifo, uqinisekisa unyango olufanelekileyo.
Umzamo weHlabathi ekulweni uDengue
● Amanyathelo oluntu lukarhulumente
Imibutho yezeMpilo yeHlabathi, oorhulumente, kunye nee-NGOs zibandakanyeka ngokuthintela i-devoe ngolawulo lwe-vector, iphononongo, kunye nephulo lokugonya. Iinkqubo zemfundo yoluntu kunye nezemfundo zikwadlala indima ebalulekileyo ekunciphiseni ukuhanjiswa kwezifo.
● Uphando kunye neenzame zophuhliso
Uphando oluqhubekayo lujolise kuphuhliso logonyo, unyango lwe-antiviral, kunye nezixhobo zokuxilonga. Ukusebenzisana phakathi kwenzululwazi, ababoneleli bezempilo, kunye ne-dengue fever i-Igg kunye nabathengisi be-IGM sisitshixo sokuqhubela phambili le mizamo kunye nokuphucula iziphumo zesigulana.
Umkhombandlela wexesha elizayo kuphando lwe-Dengue
● Itekhnoloji yokuxilonga
Ukuhambela phambili kubuchwepheshe bokuxilonga, ezinjengeekhithi zovavanyo ngokukhawuleza kunye nenqaku - Yee-- injongo yokukhathalela, injongo yokuphucula isantya kunye nokuchaneka kwe-dengoma. Ezi zicelo zintsha zibaluleke kakhulu kubutyebi - Useto olulinganiselweyo apho izibonelelo zelebhu ziyasilela.
● Izicwangciso zokupheliswa
Izicwangciso zokupheliswa kweChidee zibandakanya ukuphuhlisa isitofu sokugonya jikelele ngokuchasene nako konke ukuphelelwa yi-dengue serotypes, ukuphucula amanyathelo olawulo lwe-vector, kunye nokukhuthaza intsebenziswano yamanye amazwe. Ezi nzame, zidityaniswe nemigaqo-nkqubo yempilo yoluntu, inokunciphisa kakhulu ifuthe lika-Denguue Globall.
Iprofayile yeNkampani: u-mgono
I-Hangzhou Munotech Coutech Coutech Coutech Co., Ltd. liziko lobuvulindlela kwiqela le-MUFON, kwimfundo ekuphuhlisweni kweeproteni kunye neekhithi zovavanyo ezikhawulezayo kwi-vitro. Idume ngetyala le-R & D le-R & D i-Munos, u-Munos Gxibelela njengomnikezeli weemveliso zovavanyo lwezilwanyana kwaye wanda kwifotisti yonyango. Ukugxila kwiimvavanyo ezikhawulezayo zeVector - I-Borne, edluliselwa ngokwesondo, izifo zokuphefumla, kunye nezifo zokugaya, ugogo uzibophelele ekuphuculeni izisombululo zokuxilonga kwimpilo yolwazi lomntu kunye nezilwanyana. Ngokugxininisa okuqinileyo kumgangatho kunye nezinto ezintsha, ugono unegalelo elikhulu kuqoqosho lwempilo yehlabathi.
IXESHA LOKUQALA: 2025 - 01 - 19 15:08:02